Regulation of Glucokinase in Pancreatic Beta Cells
نویسندگان
چکیده
منابع مشابه
Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells.
We have recently shown that leucine culture upregulates ATP synthase beta-subunit (ATPSbeta) and increases ATP level, cytosolic Ca(2+), and glucose-induced insulin secretion in rat islets. The aim is to test whether glucokinase expression is also affected in rat islets and its role in glucose sensitization during leucine culture. Leucine culture increased glucose-induced NAD(P)H level at 1 and ...
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Franz Matschinsky, * Yin Liang, * Prabakaran Kesavan, * Liqun Wang, * Philippe Froguel,t Gilberto Velho,t Daniel Cohen,t M. Alan Permutt,I Yukio Tanizawa,1 Thomas L. Jetton,11 Kevin Niswender,11 and Mark A. Magnuson,, *Department ofBiochemistry and Biophysics, and the Diabetes Research Center, University ofPennsylvania, Philadelphia, Pennsylvania 19104; tCentre d'Etude du Polymorphisme Humain, ...
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Glucokinase (GK) serves as glucose sensor in pancreatic -cells and in other glucose sensor cells in the body. Biochemical genetic studies have characterized many activating and inactivating GK mutants that have been discovered in patients with hyperinsulinemic hypoglycemia or diabetes, all inherited as autosomal dominant traits. Mathematical modeling of the kinetic data of recombinant human wil...
متن کاملRegulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells.
Glucokinase (EC 2.7.1.2) is the signal-recognition enzyme in pancreatic B-cells for initiation of glucose-induced insulin secretion. We show here that both the glucokinase and glucose-transporter GLUT-2 genes are regulated physiologically. Fasting decreased B-cell glucokinase and glucose-transporter GLUT-2 mRNA in pancreatic B-cells as well as in liver, whereas refeeding induced expression of b...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.2469